| Date | Opponent | Location | Time/Result | |  | | Feb. 19, 2010 | VCU | Charleston, S.C. | 5-7 L | Recap | Box | | Feb. 20, 2010 | VCU | Charleston, S.C. | 5-9 L | Recap | Box | | Feb. 21, 2010 | VCU | Charleston, S.C. | 5-2 W | Recap | Box | | Feb. 23, 2010 | Furman  | Charleston, S.C. | 7-5 W | Recap | Box | | Feb. 26, 2010 | Virginia Tech  | Charleston, S.C. | 2-17 L | Recap | Box | | Feb. 27, 2010 | Virginia Tech | Charleston, S.C. | 2-4 L | Recap | Box | | Feb. 28, 2010 | Virginia Tech  | Charleston, S.C. | 1-13 L | Recap | Box | | Mar. 3, 2010 | @ College of Charleston | Patriots Point, S.C, | 7-12 L | Recap | Box | | Mar. 5, 2010 | Holy Cross | Charleston, S.C. | 7-6 W | Recap | Box | | Mar. 6, 2010 | Holy Cross (Game One) | Charleston, S.C. | 10-6 W | Recap | Box | | Mar. 6, 2010 | Holy Cross (Game Two) | Charleston, S.C. | 3-8 L | Recap | Box | | Mar. 9, 2010 | USC Upstate  | Charleston, S.C. | 8-4 W | Recap | Box | | Mar. 10, 2010 | Georgia Southern | Charleston, S.C. | 6-8 L | Recap | Box | | Mar. 12, 2010 | @ #6 Florida | Gainesville, Fla. | 0-6 L | Recap | Box | | Mar. 13, 2010 | @ #6 Florida | Gainesville, Fla. | 10-16 L | Recap | Box | | Mar. 14, 2010 | @ #6 Florida | Gainesville, Fla. | 6-3 W | Recap | Box | | Mar. 16, 2010 | @ USC Upstate | Spartanburg, S.C. | 8-5 W | Recap | Box | | Mar. 17, 2010 | Savannah State  | Charleston, S.C. | 9-1 W | Recap | Box | | Mar. 19, 2010 | #8 Coastal Carolina*  | Charleston, S.C. | 5-7 L | Recap | Box | | Mar. 20, 2010 | #8 Coastal Carolina*  | Charleston, S.C. | 13-29 L | Recap | Box | | Mar. 23, 2010 | @ Savannah State | Savannah, Ga. | 12-6 W | Recap | Box | | Mar. 24, 2010 | College of Charleston  | Charleston, S.C. | 9-28 L | Recap | Box | | Mar. 26, 2010 | @ #28 VMI* | Lexington, Va. | 3-13 L | Recap | Box | | Mar. 27, 2010 | @ #28 VMI (Game One)* | Lexington, Va. | 1-0 W | Recap | Box | | Mar. 27, 2010 | @ #28 VMI (Game Two)* | Lexington, Va. | 2-7 L | Recap | Box | | Mar. 30, 2010 | @ College of Charleston | Patriots Point, S.C. | 4-9 L | Recap | Box | | Mar. 31, 2010 | @ #25 The Citadel | Charleston, S.C. | 0-5 L | Recap | Box | | Apr. 2, 2010 | @ Radford* | Radford, Va. | 7-5 W | Recap | Box | | Apr. 3, 2010 | @ Radford (Game One)* | Radford, Va. | 9-6 W | Recap | Box | | Apr. 3, 2010 | @ Radford (Game Two)* | Radford, Va. | 3-9 L | Recap | Box | | Apr. 6, 2010 | The Citadel  | Charleston, S.C. | 8-7 W | Recap | Box | | Apr. 7, 2010 | @ Furman | Greenville, S.C. | 9-8 W | Recap | Box | | Apr. 9, 2010 | Winthrop* | Charleston, S.C. | 7-5 W | Recap | Box | | Apr. 10, 2010 | Winthrop* | Charleston, S.C. | 1-2 L | Recap | Box | | Apr. 11, 2010 | Winthrop* | Charleston, S.C. | 3-7 L | Recap | Box | | Apr. 13, 2010 | @ UNC Wilmington | Wilmington, N.C. | 4-5 L | Recap | Box | | Apr. 16, 2010 | @ Presbyterian College* | Clinton, S.C. | 7-14 L | Recap | Box | | Apr. 17, 2010 | @ Presbyterian College* | Clinton, S.C. | 1-10 L | Recap | Box | | Apr. 18, 2010 | @ Presbyterian College* | Clinton, S.C. | (10 innings) 9-8 W | Recap | Box | | Apr. 21, 2010 | @ #6 Florida State | Tallahassee, Fla. | 4-12 L | Recap | Box | | Apr. 23, 2010 | Gardner-Webb*  | Charleston, S.C. | 18-4 W | Recap | Box | | Apr. 24, 2010 | Gardner-Webb (Game One)*  | Charleston, S.C. | 8-9 L | Recap | Box | | Apr. 24, 2010 | Gardner-Webb (Game Two)*  | Charleston, S.C. | (10 innings) 4-5 L | Recap | Box | | May 7, 2010 | Liberty* | Charleston, S.C. | 5-7 L | Recap | Box | | May 8, 2010 | Liberty*  | Charleston, S.C. | 1-4 L | Recap | Box | | May 9, 2010 | Liberty*  | Charleston, S.C. | 4-13 L | Recap | Box | | May 11, 2010 | @ Georgia Southern | Statesboro, Ga. | 7-12 L | Recap | Box | | May 12, 2010 | @ #7 South Carolina | Columbia, S.C. | 2-10 L | Recap | Box | | May 14, 2010 | @ UNC Asheville* | Asheville, N.C. | 9-13 L | Recap | Box | | May 15, 2010 | @ UNC Asheville* | Asheville, N.C. | 3-4 L | Recap | Box | | May 16, 2010 | @ UNC Asheville* | Asheville, N.C. | 4-5 L | Recap | Box | | May 18, 2010 | UNC Wilmington | Charleston, S.C. | 5-6 L | Recap | Box | | May 20, 2010 | High Point*  | Charleston, S.C. | 7-15 L | Recap | Box | | May 21, 2010 | High Point*  | Charleston, S.C. | (13 innings) 8-10 L | Recap | Box | | May 22, 2010 | High Point*  | Charleston, S.C. | (8 innings) 11-16 L | Recap | Box |
| | Record: 17-38 (6-20 BSC) Home events are in bold. * - indicates Big South Conference event All times are Eastern. |
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